Research Progress on Traditional Chinese Medicine Regulation of Inflammatory-Related Signaling Pathways in the Intervention of Diabetic Cardiomyopathy
Abstract：Diabetic cardiomyopathy (DCM) is a common and severe cardiovascular complication in elderly diabetic patients (age ≥ 60 years), characterized pathologically by myocardial cell degeneration, apoptosis, interstitial fibrosis, and microvascular dysfunction. Modern studies have shown that the pathogenesis of DCM is closely related to the interaction of multiple factors such as cardiac metabolic disorders, chronic inflammatory responses, and oxidative stress imbalance [1]. Among these, inflammation plays a key role in the occurrence and progression of DCM. Insulin resistance and hyperinsulinemia can activate relevant inflammatory signaling pathways, promoting the release of pro-inflammatory factors such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and IL-1β, thereby exacerbating myocardial injury [2]. Long-term overexpression of pro-inflammatory factors can drive macrophages to polarize toward the M1 phenotype and stimulate fibroblast proliferation, thus amplifying myocardial cell damage and accelerating the process of myocardial fibrosis [3].
Keywords：Diabetic cardiomyopathyTraditional Chinese medicineMolecular targeted therapySignaling pathway
Publication Date：2025-12-15
Online Publishing Date：2025-12-29(First online date of this platform, not the publication date of the document)
Pages：3( 1752-1754 )