Correlation of upper limb motor function and attention recovery in stroke patients after different frequencies of rTMS
PEI Zhongjuan
JIANG Kang
LIU Yang
Abstract：Objective To explore the correlation between different-frequency repetitive transcranial magnetic stimulation(rTMS)and the recovery of upper-limb motor function as well as attention in stroke patients.Methods A total of 110 hospitalized stroke patients admitted to our department between June 2021 and June 2024 were enrolled,and then randomly divided by odd-even numbering into sham-rTMS group(n=38),low-frequency rTMS group(3 Hz,n=35)and high-frequency rTMS group(10 Hz,n=37).All groups received corresponding rTMS treatment and conventional upper-limb rehabilitation training at the same time,for 4 weeks.Resting motor threshold of the lesioned hemisphere was measured before and after treatment.Upper-limb motor function was evaluated with the Fugl-Meyer assessment-upper limb(FMA-UL),and attention and global cognitive status were evaluated with Montreal Cognitive Assessment(MoCA).Pearson correlation analysis was applied to analyze the correlation between total FMA-UL score and MoCA attention-related sub-items.Results The FMA-UL scores were increased significantly after treatment in all three groups(P＜0.05,P＜0.01).Both low-and high-frequency rTMS produced higher total MoCA attention-domain scores and 100-minus-7 serial subtraction task scores than sham stimulation(5.17±0.75,5.30±0.52 vs 4.40±0.98,P＜0.05;2.43±0.50,2.35±0.69 vs 1.87±0.88,P＜0.05).High-frequency rTMS further outperformed low-frequency rTMS in forward/backward digit-span task scores(1.97±0.41 vs 1.77±0.43,P＜0.05).Pearson correlation analysis showed positive correlations of total FMA-UL score with total MoCA attention-domain score,forward/backward digit-span score,and 100-minus-7 task score(r=0.369,r=0.288,r=0.311,P＜0.01).Conclusion Both low-and high-frequency rTMS can effectively promote recovery of upper-limb motor function and attention after stroke,and motor improvement is correlated with attention recovery.
Keywords：stroketranscranial magnetic stimulationattentionupper limb motor function
Publication Date：2025-12-15
Online Publishing Date：2025-12-29(First online date of this platform, not the publication date of the document)
Pages：5( 1722-1726 )