Association between serum triglyceride level and mortality risk of Alzheimer's disease in the elderly
WANG Xiaona
SHENG Li
XIAO Wenkai
TIE Ruping
LIU Xinyan
YE Ping
ZHENG Jin
Abstract：Objective To investigate the relationship between triglyceride(TG)level and the risk of death from Alzheimer's disease.Methods A total of 4 726 subjects were enrolled in this study,including 4 270 participants from the NHANES database(1999-2018)and 456 individuals from a community health check-up in a Beijing community between September 2007 and January 2009.The levels of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and TG were detected.The subjects were divided into four groups based on TG quartiles:Q1(0-0.80 mmol/L,823 cases),Q2(0.81-1.16 mmol/L,1 298 cases),Q3(1.17-1.72 mmol/L,1 350 cases)and Q4(1.73-6.34 mmol/L,1 255 cases).General clinical data was collected.Cox proportional hazards regression model was used to assess the association between TG and the risk of Alzheimer's disease-related death.Results Significant differences were observed among the four groups in terms of age,female,body mass index,education level,smoking,alcohol consumption,TC,TG,LDL-C and HDL-C levels,ratios of diabetes,hypertension and coronary heart disease,and proportions of antihypertensive and lipid-lowering medication use(P＜0.01).During a median follow-up time of 8.98 years,108 Alzheimer's disease-related deaths were recorded,with an incidence rate of 2.54 cases per 1000 person-years.The cumulative risk of Alzheimer's disease-related deaths was notably higher in the Q4 group than the Q1 group(P＜0.05).After adjusting for smoking,alcohol consumption,body mass index,TC and LDL-C levels,diabetes status,hypertension,heart failure,coronary heart disease,stroke,and lipid-lowering medication use,Cox proportional hazards regression model revealed that the Q3 and Q4 groups had significantly increased risks of Alzheimer's disease-related death than the Q1 group(HR=2.354,95％CI:1.041-6.113,P＜0.05;HR=2.583,95％CI:1.091-6.362,P＜0.05).Moreover,a significant increasing trend was observed across the Q2,Q3,and Q4 groups(Ptrend＜0.01).Conclusion Elevated TG level is significantly associated with an increased mortality rate from Alzheimer's disease,suggesting that hypertriglyceridemia may exacerbate the risk of death in Alzheimer's disease patients.
Keywords：triglyceridesAlzheimer diseaseproportional hazards modelscholesterolLDL
Publication Date：2025-12-15
Online Publishing Date：2025-12-29(First online date of this platform, not the publication date of the document)
Pages：5( 1698-1702 )