Value of saccadic features in the early diagnosis and symptom assessment of Parkinson's disease
WANG Miao
YIN Xi
YIN Chunyu
ZHAO Wuji
WU Junru
ZHANG Mingsha
LI Xuemei
GAO Zhongbao
Abstract：Objective To investigate the value of saccadic features in the diagnosis and symptom assement of Parkinson's disease(PD).Methods A total of 76 PD patients(PD group)and 37 healthy controls(control group)admitted in the Movement Disorders Clinic of Chinese PLA General Hospital between February 2024 and July 2025 were recruited in this study.According to the results of modified Hoehn-Yahr(mH&Y)staging,the PD patients was further divided into an early PD subgroup(stage≤ 1.5,37 cases)and a moderate-stage PD subgroup(stage≥ 2,39 cases).All participants underwent prosaccade(PS),antisaccade(AS),and memory-guided saccade(MGS)tests using a video-based eye tracker.ROC curves were plotted to evaluate diagnostic efficacy,and Spearman correlation analysis was carried out to explore the relationships between saccadic features and clinical features.Results Compared with the control group,the PD group exhibited significantly increased incidences of PS,AS and MGS errors and longer AS and MGS latencies,while lower accuracy rates of PS and MGS,lower gains in PS,AS and MGS,and reduced peak velocities of AS and MGS(P＜0.05,P＜0.01).The prolonged AS latency and decreased PS accuracy rate were influencing factors for PD(P＜0.05,P＜0.01),and prolonged AS latency was an influencing factor for early PD(P＜0.01).ROC curve analysis indicated that the AUC value of combining PS accuracy rate and AS latency in differentiating PD from control individuals was 0.916,and the value of AS latency in differentiating early PD from control individuals was 0.840.Spearman correlation analysis revealed that AS latency was positively correlated with the score of the third part and the axial subscore of Movement Disorder Society-Unified Parkinson's Disease Rating Scale(ρ=0.386,95％CI:0.170-0.567,P=0.040;ρ=0.373,95％CI:0.154-0.557,P=0.047),and MGS latency was also positively correlated with the axial subscore(ρ=0.411,95％CI:0.198-0.517,P=0.024).Conclusion Prolonged AS latency may serve as a biomarker for diagnosing early-stage PD.Both AS and MGS latencies are closely associated with motor symptoms(particularly axial symptoms)of PD patient,showing their potential application value in assessing symptom and disease progression.
Keywords：Parkinson diseaseeye movementsearly diagnosissymptom assessment
Publication Date：2025-12-15
Online Publishing Date：2025-12-29(First online date of this platform, not the publication date of the document)
Pages：6( 1611-1616 )