New Insights in Ischemic Stroke Research: Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes (cGAS-STING) Signaling Pathway
Abstract：Ischemic stroke, as a neurological disease, is characterized by temporary or permanent reduction in local cerebral blood flow, which has a high incidence, high disability rate, and poor prognosis, causing a huge social burden worldwide [1]. After an ischemic stroke occurs, necrotic neurons release cytoplasmic double-stranded DNA, which is a potential damage-associated molecular pattern that can activate the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway.
Keywords：StrokeBlood-brain barrierInflammatory responseOxidative stressProgrammed cell death
Publication Date：2025-11-15
Online Publishing Date：2025-12-02(First online date of this platform, not the publication date of the document)
Pages：4( 1593-1596 )