Correlation of hepatic fibrosis markers and PVP with poor prognosis risk in patients with CHF

ZHANG Nayi; LIU Jie; LI Zongkui; YU Zhuqin

doi:10.3969/j.issn.1009-0126.2025.11.012

Abstract：Objective To explore the relationship between the levels of hepatic fibrosis markers and peripheral venous pressure(PVP)in patients with chronic heart failure(CHF),as well as their correlation with the risk of poor prognosis in these patients.Methods A retrospective study was conducted on 216 elderly CHF patients admitted in Department of Cardiology,Qingdao Sixth People's Hospital from June 2021 to December 2024.Based on the occurrence of adverse cardiovascular events during 1-year follow-up,the patients were divided into a poor prognosis group(94 cases)and a good prognosis group(122 cases).The levels of hepatic fibrosis markers and PVP at discharge were collected.Multivariate logistic regression analysis was applied to explore the independent association of the marker levels and PVP with risk of poor prognosis.Results The good prognosis group had significantly reduced PVP,and lower levels of NT-proBNP,hyaluronic acid,type Ⅲ procollagen(PCⅢ),laminin(LN),type Ⅳ collagen(CⅣ),and 7S domain of type Ⅳ collagen N-terminal propeptide(P4NP 7S)when compared with the poor prognosis group(P＜0.05,P＜0.01).PVP was positively correlated with P4NP 7S,hyaluronic acid,CⅣ,PCⅢ and LN(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that NT-proBNP,PVP,hyaluronic acid,CⅣ,and P4NP 7S were independent risk factors for poor prognosis in CHF patients(P＜0.05,P＜0.01).ROC curve analysis revealed that the AUC value of combined hepatic fibrosis markers and PVP in predicting poor prognosis in CHF patients was 0.946(95％CI:0.907～0.972).Conclusion The levels of hepatic fibrosis markers are closely correlated with PVP in CHF patients.Combination of P4NP 7S,hyaluronic acid,CⅣ,and PVP can be used to assess the risk of adverse cardiovascular events and predict the prognosis of CHF patients.