Prognostic value of perfusion MRI in elderly patients with posterior circulation cerebral ischemia after interventional therapy

Luo Huafeng; Zhu Yanli; Wang Dongfang; Mao Rongyan

doi:10.3969/j.issn.1009-0126.2025.10.024

Abstract：Objective To investigate the prognostic value of perfusion MRI in elderly patients with posterior circulation cerebral ischemia after interventional therapy.Methods A prospective study was conducted on 200 patients with posterior circulation cerebral ischemia who received interven-tional therapy in our hospital from June 2021 to March 2024.According to the prognosis,they were divided into a good prognosis group(142 patients)and a poor prognosis group(58 patients).The detection rate of abnormal sequences and related parameters were compared between the two groups.ROC curve analysis was adopted to evaluate the diagnostic efficiency of cerebral blood vo-lume(CBV),time to peak(TTP),mean transmit time(MTT)and cerebral blood flow(CBF)alone and combined together.Results The poor prognosis group had significantly higher abnor-mal detection rates than the good prognosis group(all P＜0.05).Obvious differences were observed between the two groups in terms of lesion location,stenosis rate,and CBF values in bilateral occipital lobes and cerebelli(all P＜0.01).The good prognosis group exhibited higher CBV and CBF values and lower TTP and MTT values than the poor prognosis group(P＜0.01).The above four values combined together showed better diagnostic efficiency than any single va-lues and obtained biggest AUC value,and the cut-off value of CBV,TTP,MTT,and CBF was 751.23 ml,21.03 s,590.55 s,and 257.88 ml/(100 g·min),respectively.Conclusion The com-bined diagnosis of perfusion MRI indicators can significantly improve the prognostic efficiency after interventional therapy in elderly patients with posterior circulation cerebral ischemia.