Relationship between ultrasound differences of bilateral middle cerebral arteries and prognosis of AACIS after endovascular treatment
Li Lin
Xie Haiyang
Qin Yankun
Abstract：Objective To investigate the blood flow difference of transcranial Doppler ultrasound of bilateral middle cerebral arteries in patients with acute anterior circulation ischemic stroke(AACIS)after endovascular treatment,and analyze the influencing factors for prognosis of AACIS patients treated with stent combined with thrombolysis.Methods A retrospective analy-sis was conducted on 168 AACIS patients undergoing mechanical embolectomy in our department from May 2020 to April 2022.According to the treatment regimens,they were divided into simple thrombolysis group(72 patients)and combined thrombolysis group(96 patients).The combined thrombolysis group was assigned into good prognosis subgroup(65 cases)and poor prognosis subgroup(31 cases)according to the score Modified Rankin scale(mRS).Kaplan-Meier curve and multivariate logistic regression analyses were employed to identify the influencing factors for the poor prognosis in AACIS patients.Results Kaplan-Meier survival curve analysis showed that the combined thrombolysis group was associated with a good prognosis(P=0.013).After treatment,the combined thrombolysis group obtained significantly higher average blood flow velocity(Vm)of middle cerebral artery(MCA)and Alberta stroke program early computed tomography score(ASPECTS)than the simple thrombolysis group(P＜0.01).The good prognosis subgroup had significantly younger age,larger ratios of blood sugar ≤6.8 mmol/L and ASPECTS＞2,higher collateral circulation score in MCA region,and elevated Vm than the poor prognosis subgroup(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that blood glucose ≤ 6.8 mmol/L,collateral circulation score in MCA region,ASPECTS＞2 and Vm were protective fac-tors for good prognosis of AACIS patients(P＜0.05,P＜0.01).Conclusion Stent combined with thrombolytic therapy for AACIS has a lower risk for poor prognosis,and blood glucose ≤6.8 mmol/L,higher Tan score,DWI-ASPECTS＞2,and higher Vm are protective factors.
Keywords：strokemiddle cerebral arteryblood flow velocityultrasonographydopplertranscra-nial
Publication Date：2025-10-15
Online Publishing Date：2025-10-16(First online date of this platform, not the publication date of the document)
Pages：5( 1390-1394 )