Carotid ultrasound combined with TNF-α and receptor-interacting protein kinase 1 in evaluating prognosis of acute ischemic stroke
Jiang Hao
Wei Milin
Shi Yingna
Abstract：Objective To analyze the prognostic value of carotid ultrasound quantitative parameters combined with serum TNF-α and receptor-interacting protein kinase 1(RIPK1)levels for patients with acute ischemic stroke(AIS).Methods A total of 110 AIS patients admitted in our hospital from February 2020 to May 2024 were enrolled,and according to their modified Rankin scale(mRS)score after 3 months,they were divided into a good prognosis group(76 cases)and a poor prognosis group(34 cases).The carotid ultrasound quantitative parameters such as intima-media thickness(CIMT),end diastolic velocity(EDV)and peak systolic velocity(PSV)and serum TNF-α and RIPK1 levels were detected.The relationship of the parameters and the serum levels with prognosis was analyzed.Results The poor prognosis group had significantly higher carotid CIMT and EDV values and serum levels of TNF-α and RIPK1,and lower PSV value than the good prognosis group(P＜0.01).The CIMT,PSV,EDV,TNF-α and RIPK1 were independent in-fluencing factors of prognosis of AIS patients(P＜0.01).ROC curve analysis showed that the AUC value of CIMT,PSV,EDV,TNF-α and RIPK1 combined together in predicting the poor prognosis of AIS patients was 0.979,with a sensitivity of 94.10％and a specificity of 75.00％.Conclusion Carotid ultrasound quantitative parameters combined with serum TNF-α and RIPK1 levels can effectively assess the prognosis of AIS patients,with high predictive value.
Keywords：strokecarotid arteriesultrasonographydopplertumor necrosis factor-alphaprognosis
Publication Date：2025-10-15
Online Publishing Date：2025-10-16(First online date of this platform, not the publication date of the document)
Pages：4( 1386-1389 )