Research Progress on Curcumin Regulation of NLRP3 Inflammasome in Atherosclerosis
Abstract：Atherosclerosis (AS), as a chronic inflammatory disease, is closely related to the abnormal activation of immune cells and the cascade release of inflammatory factors. Recent studies have shown that the nucleotide-binding oligomerized domain-like receptor protein 3 (NLRP3) plays a central regulatory role in pathological processes such as vascular endothelial injury, foam cell formation, and plaque instability by mediating the maturation and release of pro-inflammatory factors such as interleukin (IL)-1β and IL-18. However, existing drugs still face problems such as insufficient targeting and significant adverse reactions when precisely intervening in the NLRP3 signaling pathway, which has prompted researchers to turn to the development of natural active substances.
Keywords：CurcuminNLR familyNOD-like receptor protein 3AtherosclerosisInterleukin class
Publication Date：2025-09-15
Online Publishing Date：2025-09-29(First online date of this platform, not the publication date of the document)
Pages：3( 1283-1285 )