Research Progress on Autophagy Regulation of Microglial Function in Ischemic Stroke
Abstract：Ischemic stroke (IS), as the second leading cause of death worldwide, accounts for approximately 85% of all stroke cases, with its high incidence and mortality imposing a heavy burden on families and society [1]. IS originates from a temporary or permanent reduction in local cerebral blood flow, leading to tissue hypoxia and insufficient glucose supply. Under ischemic and hypoxic conditions, damaged neurons release damage-associated molecular patterns (DAMPs), cytokines, and chemokines, causing neuronal death and ultimately resulting in motor, sensory, and cognitive dysfunction [2].
Keywords：AutophagyMitophagyChaperone-mediated autophagyStrokeMicroglia
Publication Date：2025-08-15
Online Publishing Date：2025-08-21(First online date of this platform, not the publication date of the document)
Pages：4( 1121-1124 )