Research Progress on the Mechanism of the Association between Cardiovascular Disease and Insulin Resistance and Its Relationship with Triglyceride-Glucose Index
Abstract：Cardiovascular disease (cardiovascular disease, CVD) seriously threatens the health of residents in China and is the leading cause of death and disease burden among Chinese residents. The risk factors of CVD include smoking, age, genetics, and cardiovascular metabolic diseases. Among them, cardiovascular metabolic diseases lead to metabolic abnormalities, resulting in adverse cardiovascular events. Insulin resistance (insulin resistance, IR) is the core pathophysiological basis of cardiovascular metabolic diseases and is closely related to the occurrence and development of various CVDs. IR promotes the progression of coronary atherosclerosis through mechanisms such as endothelial damage and imbalance of coagulation and fibrinolytic systems; at the same time, IR can also cause enhanced myocardial oxidative stress and abnormal energy metabolism, leading to cardiac systolic and/or diastolic dysfunction, ultimately resulting in the occurrence of heart failure (heart failure, HF). The inflammatory response, oxidative stress, and atrial remodeling caused by IR significantly increase the prevalence of atrial fibrillation (atrial fibrillation, AF).
Keywords：Cardiovascular diseaseMetabolic diseaseInsulin resistanceBlood glucose index
Publication Date：2025-08-15
Online Publishing Date：2025-09-04(First online date of this platform, not the publication date of the document)
Pages：4( 1114-1117 )