Research Progress on the Mechanism of Berberine in Preventing and Treating Atherosclerosis by Regulating Lipid Metabolism
Abstract：Atherosclerosis (AS) is a chronic inflammatory disease characterized by the accumulation of lipids and inflammatory cells in the walls of large and medium arteries, forming the main pathological basis for ischemic cardiovascular and cerebrovascular diseases. This pathological process involves multiple stages, including vascular endothelial injury, lipid deposition, infiltration of inflammatory cells, proliferation of smooth muscle cells, and remodeling of the extracellular matrix, which collectively promote the formation of atherosclerotic plaques in the arterial wall. Ultimately, this may lead to narrowing of the vascular lumen, thrombosis, and even severe clinical outcomes such as myocardial infarction and cerebrovascular accidents [1-2]. Given its serious health threat, finding effective prevention and treatment strategies is of great significance for reducing the incidence of cardiovascular and cerebrovascular diseases.
Keywords：BerberineAtherosclerosisClinical researchLipid-lowering effectTraditional Chinese medicine
Publication Date：2025-08-15
Online Publishing Date：2025-08-21(First online date of this platform, not the publication date of the document)
Pages：4( 1106-1109 )