Clinical value of combined detection of inflammatory indicators and coagulation function indicators in early diagnosis of MI patients
Chen Dongmei
Xuan Ling
Wang Maolin
Abstract：Objective To analyze the detection significance of platelet to lymphocyte ratio(PLR),lymphocyte to monocyte ratio(LMR),neutrophil to lymphocyte ratio(NLR)and coagulation function indicators in patients with non-ST-segment elevation myocardial infarction(NSTEMI)and patients with ST-segment elevation myocardial infarction(STEMI).Methods One hundred and eighty-two elderly patients with acute myocardial infarction admitted to department of cardio-vascular medicine of the Third People's Hospital of Bengbu were selected from January 2021 to December 2023,and were divided into NSTEMI group(104 cases)and STEMI group(78 cases)according to electrocardiogram characteristics.Additionally,80 healthy subjects receiving physical examination in the Third People's Hospital of Bengbu were assigned into the control group.The levels of PLR,NLR,LMR,D-dimer and fibrinogen(FIB)were measured after admission.Serum PLR,NLR,LMR,D-dimer and FIB levels were compared among the three groups.The evaluation model based on PLR,NLR,LMR,D-dimer and FIB was constructed by binary logistic regression analysis.ROC curve was adopted to analyze the value of PLR,NLR,LMR,D-dimer and FIB in evaluating NSTEMI patients and STEMI patients.Results The levels of serum PLR,NLR,LMR,D-dimer and FIB in the STEMI group and the NSTEMI group were significantly higher than those in the control group(P＜0.05).The serum PLR,NLR,LMR,D-dimer and FIB were independent influencing factors for STEMI and NSTEMI patients(OR=25.078,95％CI:3.147-199.865;OR=32.852,95％CI:4.398-245.417;OR=28.703,95％CI:3.310-248.867;OR=67.491,95％CI:8.518-534.729;OR=46.759,95％CI:8.219-266.006;OR=2.573,95％CI:1.026-6.451;OR=3.442,95％CI:1.750-6.768,OR=2.971,95％CI:1.799-4.907;OR=68.375,95％CI:12.598-371.103;OR=7.471,95％CI:1.759-31.737,P＜0.05).ROC curve indicated that the area under the curve(AUC),sensitivity and specificity of combination of serum PLR,NLR,LMR,D-dimer and FIB were 0.996,99.04％and 95.00％in evaluating NSTEMI,and were 0.995,94.87％and 97.50％in assessing STEMI,and the efficiency of combined evaluation was better than that of single evaluation(P＜0.05).Conclusions PLR,NLR,LMR,D-dimer and FIB in NSTEMI patients and STEMI patients are significantly increased.The combined determination of various indicators has important reference value in the early diagnosis of NSTEMI and STEMI.
Keywords：ST elevation myocardial infarctionnon-ST elevated myocardial infarctionlympho-cytesfibrinogenlogistic models
Publication Date：2025-08-15
Online Publishing Date：2025-08-21(First online date of this platform, not the publication date of the document)
Pages：5( 1021-1025 )