Molecular Mechanisms and Therapeutic Advances of Copper Metabolism and Copper-Dependent Cell Death in Cardiovascular Diseases
Abstract：Copper-dependent cell death is a recently discovered copper-dependent cell death mechanism, which involves the accumulation of copper ions in mitochondria, leading to energy metabolism failure through the oligomerization of lipidated proteins mediated by ferrodoxin 1 and the collapse of the tricarboxylic acid cycle [1]. Previous studies have shown that imbalance in copper homeostasis is closely related to myocardial ischemia-reperfusion injury, atherosclerosis, and heart failure [2]. Therapeutic strategies targeting copper-dependent cell death include copper chelators, nanomaterials, and small molecule inhibitors, but their tissue specificity and long-term safety still need further exploration. This review systematically summarizes the molecular mechanisms and therapeutic translational prospects of copper-dependent cell death in cardiovascular diseases, aiming to provide a theoretical basis for individualized copper regulation in patients.
Keywords：CopperChelatorsCardiovascular DiseasesOxidative Stress
Publication Date：2025-07-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 965-968 )