Role of Epicardial Adipose Tissue in the Pathogenesis of Heart Failure with Preserved Ejection Fraction
Abstract：Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure, associated with comorbidities such as hypertension, diabetes, obesity, coronary heart disease, and chronic kidney disease, leading to high hospitalization rates and mortality [1]. Obesity is an important driver of the development and progression of HFpEF and is a modifiable risk factor for HFpEF; however, body mass index provides limited information about visceral obesity, and patients with similar data may have different cardiovascular risks. Epicardial adipose tissue (EAT), the closest fat tissue to the heart, located between the myocardium and the visceral layer of the pericardium, has been used as a biomarker of visceral obesity. As a metabolically active endocrine organ, EAT can produce both beneficial and harmful cytokines, which are particularly important for cardiac function. Therefore, this review discusses the mechanisms by which EAT contributes to the development and progression of HFpEF and potential therapeutic strategies.
Keywords：PericardiumAdipose TissueHeart FailureInflammationFatty Acids
Publication Date：2025-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 677-678 )