Research Progress on the Mechanisms of Myocardial Energy Metabolic Remodeling in Chronic Heart Failure
Abstract：Chronic heart failure (CHF) refers to a clinical syndrome caused by various reasons leading to abnormalities in cardiac structure and/or function, resulting in decreased cardiac pumping capacity, compensatory changes in the heart, and ultimately insufficient blood perfusion of organs and tissue damage. CHF is a common cardiovascular disease that seriously threatens human health and life. Its prevalence and mortality rate are increasing year by year, becoming an important public health issue worldwide. The main characteristics of CHF are heart failure and myocardial energy metabolic remodeling. Myocardial energy metabolism is the essential basis for maintaining normal cardiac function. During the process of CHF, the remodeling of energy metabolism within myocardial cells is one of the key mechanisms in the occurrence and development of the disease. Therefore, understanding the related mechanisms of myocardial energy metabolic remodeling in CHF is of great significance for the prevention and treatment of CHF.
Keywords：Heart FailureMyocardiumEnergy MetabolismVentricular Remodeling
Publication Date：2025-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 673-676 )