Research Progress on the Mechanism of High Mobility Group Box 1 (HMGB1) Mediating Myocardial Injury through Regulating Pyroptosis in Myocardial Infarction
Abstract：High mobility group box 1 (HMGB1) plays a key role in inflammatory responses and cell death after myocardial infarction. Pyroptosis, a newly discovered form of programmed cell death, is closely related to myocardial ischemia-reperfusion injury. Current research on death mechanisms associated with myocardial infarction still faces many challenges, especially in the identification of cell death types and their regulatory pathways, which remain incompletely understood. This review analyzes the mechanisms by which HMGB1 affects the progression of myocardial infarction through the regulation of pyroptosis, exploring the signaling pathways involved in this process and potential therapeutic targets. Based on the latest research progress, it analyzes the molecular mechanisms of HMGB1 in myocardial injury and its clinical significance, providing new insights for the treatment of myocardial infarction, aiming to provide a theoretical basis for future research and treatment strategies.
Keywords：HMGB1 proteinmyocardial infarctionpyroptosisresearch
Publication Date：2025-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 670-672 )