Effect of Yiqi Fumai Injection combined with atorvastatin on cardiac function in CHD patients with angina of Qi-Yin deficiency pattern

Zhong Baohua; Zhang Jinzhong; Wang Chunliang; Shi Shuzhen

doi:10.3969/j.issn.1009-0126.2025.05.010

Abstract：Objective To investigate the effect of Yiqi Fumai Injection combined with atorvastatin on cardiac function in elderly coronary heart disease patients with angina of Qi-Yin deficiency pat-tern.Methods A total of 122 elderly coronary heart disease patients with angina pectoris of Qi-Yin deficiency pattern admitted to our department from September 2022 to September 2023 were recruited and randomly divided into control group and observation group,with 61 cases in each group.The control group was treated with atorvastatin,and the observation group was treated with Yiqi Fumai Injection on the basis of atorvastatin.Clinical efficacy,blood lipids,B-type natri-uretic peptide level,myocardial enzymes,cardiac function,and inflammatory factors were com-pared between the two groups.Results The total effective rate was significantly higher in the observation group than the control group(95.08％vs 80.33％,x2=6.157,P＜0.05).After 4 weeks of treatment,the observation group had obviously lower levels of total cholesterol,triglyc-erides,low-density cholesterol,B-type natriuretic peptide,lactate dehydrogenase,creatine kinase,creatine kinase isoenzyme,C-reactive protein,interleukin-6 and tumor necrosis factor-α,left ven-tricular end systolic diameter,left ventricular end-diastolic diameter and left ventricular end sys-tolic volume(P＜0.05,P＜0.01),and notably higher high-density cholesterol level and left ven-tricular ejection fraction when compared with the control group(1.44±0.39 mmol/L vs 1.23±0.30 mmol/L,P=0.001;55.36±13.37％vs 50.29±10.44％,P=0.021).Conclusion Yiqi Fumai Injection combined with atorvastatin shows significantly effective in the treatment of elderly coro-nary heart disease patients with angina pectoris of Qi-Yin deficiency pattern,and can improve lipid metabolism,B-type natriuretic peptide,myocardial enzymes and cardiac function,and reduce in-flammatory factors.