The Relationship Between Neuropeptide Y Levels and the Risk of Post-Stroke Epilepsy

doi:10.3969/j.issn.1009-0126.2025.04.026

Abstract：Objective To explore the relationship between neuropeptide Y (NPY) levels and the risk of post-stroke epilepsy (PSE). Methods A total of 226 patients with acute stroke admitted to the Department of Neurology, The First Hospital of Handan, from May 2021 to July 2023 were selected. Patients were divided into PSE group (n=22) and non-PSE group (n=204) based on whether secondary epilepsy occurred within 7 days after stroke. General clinical data of the two groups were compared, and logistic regression analysis was used to analyze the influencing factors of PSE. ROC curve analysis was used to evaluate the predictive value of NPY for PSE. Results Within 7 days after stroke, the incidence of PSE was 9.73% among the 226 patients. The NIHSS score at admission, high-sensitivity C-reactive protein, and the proportion of cortical lesions in the PSE group were significantly higher than those in the non-PSE group, while NPY levels were significantly lower (P < 0.05, P < 0.01). Multivariate logistic regression analysis showed that NIHSS score at admission (OR=1.571, 95% CI: 1.103–2.238, P=0.012), lesion location (OR=5.920, 95% CI: 1.280–27.391, P=0.023), and high-sensitivity C-reactive protein (OR=2.140, 95% CI: 1.202–3.807, P=0.010) were risk factors for PSE, while NPY (OR=0.819, 95% CI: 0.750–0.895, P=0.000) was a protective factor. ROC curve analysis showed that the area under the curve for NPY in diagnosing PSE was 0.936, indicating the highest predictive value (P < 0.05). Conclusion NPY has good predictive value for PSE, and the higher the NPY level, the better the effect of inhibiting PSE occurrence.