Research Progress on the Potential Diagnostic and Therapeutic Value of Extracellular Vesicles in Parkinson's Disease
Abstract：Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide after Alzheimer's disease. The main clinical features of PD are motor symptoms such as resting tremor, rigidity, bradykinesia, and gait and posture abnormalities, as well as non-motor symptoms such as hyposmia, constipation, depression, and sleep disorders. The main pathological changes include the massive degeneration and loss of dopaminergic neurons in the substantia nigra compacta and the presence of Lewy bodies in the cytoplasm of neurons. Currently, the diagnosis of PD mainly relies on clinical manifestations, and symptomatic treatment with dopamine agonists is commonly used. However, there is a lack of effective disease-modifying treatments. Therefore, it is urgently needed to find new diagnostic biomarkers and drug targets for PD. Among them, extracellular vesicles (EVs) have attracted widespread attention and research due to their important role in the pathogenesis of PD.
Keywords：Extracellular VesiclesParkinson's DiseaseDiagnosisTherapy
Publication Date：2025-03-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 395-397 )