The Role of Cholinergic Nervous System Disorders in Alzheimer's Disease and Related Research
Abstract：Hypofunction of the cholinergic system in the basal forebrain plays an important role in the pathological changes of Alzheimer's disease (AD). Degeneration of cholinergic neurons and a reduction in choline acetyltransferase can be observed in the early stages of AD. Meanwhile, studies have confirmed that drug-induced damage to the basal forebrain cholinergic system can lead to memory and attention deficits. Therefore, the so-called 'cholinergic hypothesis' was formed. Subsequently, acetylcholinesterase inhibitors were developed as therapeutic drugs for AD, which prolong the action time of acetylcholine on its receptors, thereby leading to a 'stabilization' process of cognition and delaying the progression of pathology [1-2].
Keywords：Basal forebrainCholinergic neuronsCognitive dysfunctionAlzheimer's diseaseResearch
Publication Date：2025-03-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 392-394 )