Research Progress on the Interaction between Fibroblasts and Macrophages in Myocardial Fibrosis
Abstract：It is well known that myocardial fibrosis can damage cardiomyocytes, leading to arrhythmia and other adverse outcomes. It is a pathological process of adverse development of various cardiovascular diseases, especially as a core pathological change driving adverse cardiac remodeling in heart failure. Myocardial fibrosis mainly involves increased synthesis of extracellular matrix (ECM) and fibrous tissue, as well as the secretion of pro-fibrotic mediators by immune cells, i.e., an increase in type I and III collagen fibers in the myocardial interstitium and an increase in alpha-smooth muscle actin expression by myofibroblasts [1].
Keywords：MacrophagesFibroblastsFibrosis
Publication Date：2025-03-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 389-391 )