Research Progress on Mitochondrial Permeability Transition Pore and Myocardial Ischemia-Reperfusion Injury
Abstract：Ischemic heart disease is an important cause of cardiovascular disease-related mortality worldwide, and its incidence has been increasing year by year [1]. Early reperfusion therapy, such as coronary artery bypass grafting, thrombolytic therapy, and percutaneous coronary intervention, can significantly reduce the mortality rate of ischemic heart disease [2]. However, restoring blood supply to ischemic tissue may paradoxically exacerbate myocardial structural and functional impairment, leading to myocardial ischemia-reperfusion (ischemia reperfusion, I/R) injury [3].
Keywords：Mitochondrial Permeability Transition PoreMyocardial Reperfusion InjuryReactive Oxygen SpeciesMyocytesHeart
Publication Date：2025-03-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 377-379 )