Effects of MVD and percutaneous balloon compression on related indicators and prognosis in elderly patients with trigeminal neuralgia
Li Xiaobo
Xie Dong
Li Bo
Abstract：Objective To compare the effects of microvascular decompression(MVD)and percuta-neous balloon compression(PBC)on inflammatory factors,neurotransmitters,oxidative stress and prognosis in the treatment of trigeminal neuralgia(TN).Methods A total of 130 elderly TN patients admitted in Department of Neurosurgery of Baoding First Hospital from June 2021 to June 2023 were enrolled,and according to surgical approaches,they were divided into MVD group(64 patients)and PBC group(66 patients).The following indicators were compared between the two groups,including immediate postoperative clinical efficacy,operation time,length of hospital stay,incidence of complications,recurrence rate 1 year after surgery,serum inflammatory factors(Il-1β,IL-6,TNF-α),oxidative stress indicators(MAD,SOD,GSH-Px),and serum neurotrans-mitter[calcitonin gene-related peptide(CGRP),substance P,5-HT].Results There was no sig-nificant difference in remission rate between the MVD group and PBC group(98.4％vs 97.0％,P＞0.05).But the MVD group had obviously longer operation time and length of hospital stay,and lower incidence of complications than the PBC group(P＜0.01).Serum levels of IL-1β,IL-6,TNF-α and MAD in the MVD group at 6 h after operation were significantly higher while SOD and GSH-Px levels were significantly lower than those in the PBC group(P＜0.01).Compared with the levels before surgery,both groups had significantly increased serum levels of IL-1β,IL-6,TNF-α and MAD but reduced SOD,GSH-Px,CGRP and substance P levels at 6 h after surgery,declined IL-1β,IL-6 and TNF-α levels at 3 d after surgery,and elevated serum 5-HT level but de-creased CGRP and substance P levels at 1 month after surgery(P＜0.05).No statistical difference was seen in pain recurrence rate between the two groups at 1 year after surgery(X2=1.781,P=0.182).Conclusion Both MVD and PBC are effective treatments for senile trigeminal neuralgia,and can regulate the inflammatory factor and neurotransmitter levels.MVD has the advantage of lower incidence of postoperative complications,while PBC is superior in less trauma,shorter oper-ation time and hospital stay.
Keywords：microvascular decompression surgerytrigeminal neuralgiaoxidative stressprognosis
Publication Date：2025-03-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 332-336 )