Effect of systemic immune index on myocardial infarction events in elderly patients with coronary heart disease and type 2 diabetes mellitus
Wang Congying
Chen Kun
Wang Lili
Chen Shuxia
Gu Jian
Abstract：Objective To investigate the correlation of SII with occurrence of short-term MI in eld-erly patients with CHD complicated with T2DM.Methods A total of 382 CHD patients with con-comitant T2DM admitted in our hospital from January 2022 to January 2023 were enrolled,and according to occurrence of MI within 1 year,they were divided into a MI group(83 patients)and a non-MI group(299 patients).Clinical data were collected,and multivariate logistic regression analysis was used to determine the risk factors for MI in the patients.ROC curve was plotted to evaluate the predictive value of SII,fasting blood glucose(FPG)and their combination for 1-year MI occurrence.Kaplan-Meier curve was drawn to analyze the relationship between SII and MI.Results Multivariate logistic regression analysis showed that SII,FPG and peripheral atheroscle-rosis were risk factors for MI occurrence(OR=1.001,95％CI:1.000-1.001,P=0.001;OR=1.106,95％CI:1.016-1.203,P=0.020;OR=4.798,95％CI:2.621-8.786,P=0.000),and GLP-1RA and SGLT2i were protective factors for the occurrence(OR=0.255,95％CI:0.073-0.895,P=0.033;OR=0.474,95％CI:0.270-0.834,P=0.010).ROC curve analysis indicated showed that the AUC value of SII,FPG and their combination was 0.675,0.619 and 0.702,respectively,and the predictive performance was better in the combination than the indicator alone(P＜0.01).Kaplan-Meier curve analysis revealed that the cumulative survival rate in the high-level group was significantly lower than that in the low-level group(Plog rank＜0.01).Conclusion For the elderly T2DM patients with concomitant CHD,SII,FPG and atherosclerosis are independ-ent risk factors for MI occurrence.SII and FPG have certain predictive value for the occurrence.
Keywords：coronary diseasediabetes mellitusmyocardial infarctionregression analysisathero-sclerosisrisk factors
Publication Date：2025-03-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 280-284 )