Research Progress on Primary Progressive Aphasia in Chinese
Abstract：Primary progressive aphasia (PPA) is a neurodegenerative disorder that causes a clinical syndrome due to involvement of the language network. PPA has an insidious onset and gradually progressive symptoms, with language impairment as the initial manifestation. Neuroimaging and neuropathological studies show that most PPA patients have involvement of the language-dominant hemisphere (left hemisphere), affecting the language network. Currently, PPA is mainly classified into semantic dementia (SD), progressive non-fluent aphasia (PNFA), and logopenic progressive aphasia (LPA). Most existing PPA research is limited to Indo-European languages such as English, while research on Chinese PPA patients is relatively scarce, with most studies focusing on case reports and small-sample retrospective analyses. Chinese, as a logographic language, has a different representational system compared to alphabetic languages like English, and the cross-linguistic validity of language symptoms observed in English PPA patients remains insufficiently understood. Based on this, this review summarizes the current research progress on Chinese PPA from aspects including clinical manifestations, neuropsychological assessment, neuroimaging, pathology, and genetics, and compares it with findings from English PPA studies to describe the basic characteristics of Chinese PPA and its distinguishing features from English PPA.
Keywords：AphasiaPrimary progressiveFrontotemporal dementiaAnomiaPrimary progressive logopenic aphasia
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 254-256 )