Research Progress on mTOR-Related Signaling Pathways Mediating Autophagy in Coronary Heart Disease
Abstract：Coronary heart disease is a systemic degenerative inflammatory vascular disease. According to epidemiological data from 2023, the incidence of coronary heart disease is continuously increasing, especially among people over 50 years old [1]. The mammalian target of rapamycin (mTOR), as a key signaling transduction factor, can regulate downstream signaling pathways by sensing changes in the internal and external environment of the cell, thereby affecting various cellular responses, including cell growth, metabolism, migration, proliferation, survival, protein synthesis, cellular aging, apoptosis, and autophagy [2]. Autophagy is an important mechanism for cells to maintain homeostasis, and it plays a key role in the occurrence and development of various diseases. In recent years, more and more studies have revealed the significant role of autophagy in the pathogenesis of coronary heart disease [3]. This review will focus on the mechanisms of action and recent research progress of mTOR-related signaling pathways and their mediated autophagy in coronary heart disease.
Keywords：Coronary Heart DiseasemTOR Regulatory ProteinsPhosphatidylinositol 3-KinaseProto-Oncogene Protein c-AktResearchAutophagy
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 235-237 )