A case of cerebellar ataxia caused by glutamate decarboxylase 65 antibody-associated encephalitis
Abstract：Cerebellar ataxia is a common clinical symptom in neurology, with various causes, including ischemic cerebrovascular disease, hemorrhagic cerebrovascular disease, hereditary metabolic diseases, inflammatory diseases, and lesions involving immune mechanisms [1]. Among them, immune-mediated cerebellar ataxia is classified into two categories according to the consensus on immune-mediated cerebellar ataxia: one primarily affecting the cerebellum, and the other involving the cerebellum along with other central nervous system regions. The former can be further divided into those caused by other diseases and those caused by primary autoimmune mechanisms [2]. However, the etiology of some immune-mediated cerebellar ataxias remains unknown and cannot be classified. Cerebellar ataxia mediated by glutamate decarboxylase (glutamate decarboxylase, GAD) 65 antibodies belongs to primary autoimmune diseases. There are few reports of this condition in China. Through summarizing the diagnostic and therapeutic process of a patient with cerebellar ataxia caused by GAD65 antibody-associated encephalitis, we hope to provide clinical experience for physicians.
Keywords：Cerebellar ataxiaNeurological diseasesGlutamate decarboxylase 65
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 232-234 )