Research on Neuroimaging Biomarkers in Patients with Multiple System Atrophy
Abstract：Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by neuronal loss and glial proliferation in multiple regions of the central nervous system, including the striato-nigral region, the olivo-ponto-cerebellar region, and central autonomic structures, as well as the formation of oligodendroglial cytoplasmic inclusions. Clinically, the typical diagnosis of MSA is based on autonomic dysfunction, extrapyramidal signs, and cerebellar signs. However, early or atypical cases may be difficult to differentiate from parkinsonian overlap syndromes. Neuroimaging biomarkers provide an important auxiliary means for the clinical diagnosis and differential diagnosis of MSA.
Keywords：Multiple System AtrophyMagnetic Resonance ImagingBiomarkerStructural Magnetic Resonance
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 129-131 )