Correlation of two serum markers and electroencephalogram with infarct size and neurological function in patients with ACI

Ding Jie; Huang Jiankang; Wen Hongbo; Wang Jie; Ding Pengyu; Wang Peng

doi:10.3969/j.issn.1009-0126.2025.01.015

Abstract：Objective To explore the relationship of EEG and IGF-1 and NSE with infarct size and NIHSS score in patients with acute cerebral infarction(ACI).Methods A total of 218 patients with freshly diagnosed ACI admitted in our department from August 2021 to December 2022 were enrolled,and according to the lesion volume,they were divided into large-,medium-and small-volume groups(63,103 and 52 cases,respectively).The(δ+θ)/(α+β)ratio(DTABR),brain-spine interface(BSI),and serum IGF-1 and NSE levels were measured in these patients.The cor-relation of the above indicators with the volume of infarct volume by MRI,and NIHSS score at baseline and at 2 and 4 weeks after rt-PA thrombolysis was analyzed.Results The medium-and large-volume groups had significantly lower serum IGF-1 level,and higher NSE level and in-creased DTABR and BSI values than the small-volume group(P＜0.05).When compared with the medium volume group,the serum IGF-1 level was obviously lower,and the NSE level and DTABR and BSI values were higher in the large-volume group(P＜0.05).The DTABR and BSI values and serum NSE level were positively correlated with the infarct size(r=0.563,P=0.000;r=0.318,P=0.038;r=0.673,P=0.000)and baseline NIHSS score(r=0.499,P=0.000;r=0.362,P=0.013;r=0.750,P=0.001).The serum IGF-1 level had a negative correlation with the infarct size(r=-0.572,P=0.000)and baseline NIHSS score(r=-0.438,P=0.001).In addi-tion,positive correlations were observed in DTABR and BSI values,serum NSE level and infarct size with the 2-week and 4-week NIHSS scores,while negative correlations were seen in the ser-um IGF-1 level with the NIHSS scores at the two time points(P＜0.05,P＜0.01).Conclusion EEG parameters,IGF-1 and NSE are significantly correlated with infarct size and NIHSS score af-ter thrombolysis in ACI patients.