Correlation between serum uric acid and adverse prognosis in elderly patients with heart failure
Wang Wenyou
Zhou Ping
Zheng Juanjuan
Lü Ci
Zhang Chenchen
Wang Tong
Wang Wei
Liu Lingyan
Abstract：Objective To investigate the effect of SUA level on adverse prognosis in elderly pa-tients with HF.Methods A retrospective analysis was conducted on 1583 patients admitted to Zigong Fourth People's Hospital between December 2016 and June 2019 due to a diagnosis of HF.The patients were divided into low SUA group(≤386.8 μmol/L,523 cases),medium SUA group(386.9-523.6 µmol/L,537 cases),and high SUA group(＞523.6 μmol/L,523 cases).Multivari-ate logistic regression model was employed to assess the relationship between SUA level and ad-verse outcomes in the elderly HF patients.Results The incidence of adverse events was signifi-cantly higher in the high SUA group than that in the low SUA group in 6 months of follow-up(P＜0.05).When compared with the low SUA group,the high SUA group had a significantly in-creased risk of readmission within 6 months(RR=1.531,95％CI:1.180-1.988,P=0.001),and elevated risk of compound events(RR=1.624,95％CI:1.255-2.102,P=0.000).NYHA grade Ⅳand diabetes were independent influencing factors for 6-month adverse prognosis in elderly pa-tients HF(P＜0.05,P＜0.01).An approximately linear trend was observed in the dose-response relationship of SUA level and adverse prognosis,indicating an increased risk of short-term death,readmission,and compound events as increment of SUA level.Conclusion Higher SUA level is significantly associated with adverse prognosis in elderly HF patients.
Keywords：heart failureuric acidprognosiscorrelation of data
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1414-1418 )