Relationship of abnormal expression of serum H-FABP and SIRT1 with ventricular remodeling in elderly patients with ischemic cardiomyopathy
Lu Jun
Xuan Hongyan
Li Weiwei
Abstract：Objective To investigate the relationship between abnormal expression of serum heart-type fatty acid-binding protein(H-FABP)and silent mating type information regulation 2 homo-log-1(SIRT1)and ventricular remodeling in elderly patients with ischemic cardiomyopathy.Meth-ods A total of 200 elderly patients with ischemic cardiomyopathy admitted to our hospital from August 2022 to December 2023 were enrolled as the study group,and another 100 healthy individ-uals who took physical examinations at the same time were recruited as the control group.Accord-ing to ventricular remodeling occurred or not,the patients from the study group were divided into a ventricular remodeling subgroup(38 cases)and a non ventricular remodeling subgroup(162 cases).Serum H-FABP and SIRT1 levels were detected and compared in above groups and sub-groups.Pearson correlation analysis was used to analyze the relationship between serum H-FABP and SIRT1 levels and ventricular remodeling,and ROC curve was plotted to analyze the serum H-FABP and SIRT1 levels in diagnosing ventricular remodeling.The influencing factors of ven-tricular remodeling were analyzed by logistic regression.Results The serum H-FABP level was significantly higher,and that of SIRT1 was obviously lower in the study group than the control group(P＜0.01).The ventricular remodeling subgroup had higher serum H-FABP level but lower SIRT1 level when compared with the non ventricular remodeling subgroup(P＜0.01).Pearson correlation analysis showed that serum H-FABP level was negatively correlated with LVMI(r=-0.569,P=0.001),while serum SIRT1 level was positively correlated with LVMI(r=0.511,P=0.001).ROC curve analysis indicated that the AUC value of serum H-FABP and SIRT1 levels in diagnosing ventricular remodeling was 0.872(95％CI:0.821-0.933)and 0.848(95％CI:0.786-0.897),respectively.Logistic regression analysis suggested that serum H-FABP(OR=1.848,95％CI:1.068-3.262,P=0.032)was a risk factor,while SIRT1 was a protective factor(OR=0.687,95％CI:0.409-0.935,P=0.015)for ventricular remodeling in elderly patients with ischemic cardiomyopathy.Conclusion Elderly patients with ischemic cardiomyopathy have abnor-mally high expression of serum H-FABP and abnormally low expression of SIRT1.The expres-sion levels are correlated with the severity of ventricular remodeling,and are influencing factors for ventricular remodeling,and show good diagnostic value for ventricular remodeling.
Keywords：fatty acid-binding proteinssilent information regulatory factor 2 related enzymemyo-cardial ischemiaventricular remodeling
Publication Date：2024-10-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1158-1161 )