Effect of serum hs-cTnT level at admission on long-term cognitive function in elderly patients with mild to moderate cerebral infarction
Zhang Shuibao
Zhang Hongyu
Li Guo
Li Lin
Abstract：Objective To explore the correlation between hs-cTnT and long-term cognitive function in elderly patients with mild to moderate cerebral infarction.Methods A total of 207 inpatients with cerebral infarction admitted in our hospital from February to November 2020 were prospec-tively recruited,and according to the serum level of hs-cTnT at admission,they were divided into in a high-level group(hs-cTnT＞12 ng/L,102 cases)and a low-level group(hs-cTnT ≤12 ng/L,105 cases).Among them,190 patients completed a 3-year follow-up,including 94 from the high-level group and 96 from the low-level group.The general information and Mini-Mental Status Ex-amination(MMSE)score were compared and analyzed in the two groups.Logistic regression analy-sis was used to identify the factors affecting cognitive function of the patients at discharge and in 3 years after discharge.ROC curve was plotted to analyze the value of the serum level of hs-cTnT at admission for cognitive impairment in 3 years after discharge.Results In 3 years after dis-charge,both groups had a higher MMSE score and lower proportion of cognitive impairment when compared with the conditions at discharge(P＜0.01).The MMSE scores at discharge and 3 years after discharge were significantly lower,and the proportions of cognitive impairment at the two time points were obviously higher in the high-level group than the low-level group(P＜0.01).Logistic regression analysis showed that female,high baseline hs-cTnT level,and delirium dura-tion＞1 d were risk factors(P＜0.05,P＜0.01),while education level of college or above was a protective factor for cognitive impairment in patients with cerebral infarction at discharge(P＜0.05).Age,female,presence of cognitive impairment at discharge,and high baseline hs-cTnT level were risk factors for cognitive impairment in 3 years after discharge(P＜0.05,P＜0.01).ROC curve analysis indicated that the AUC value of baseline hs-cTnT in predicting cognitive impair-ment in 3 years after discharge was 0.732(95％CI:0.531-0.927).Conclusion High serum hs-cTnT level at admission is a risk factor for cognitive impairment in elderly patients with mild to moderate cerebral infarction at discharge and 3 years after discharge,and it can help predict long-term cognitive function in these patients.
Keywords：brain infarctiontroponin Tcognitive dysfunctionrisk factors
Publication Date：2024-09-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1054-1058 )