Predictive value of direct bilirubin in diagnosis of CHD in senile T2DM patients
Li Jiarui
Zhang Hui
Abstract：Objective To investigate the value of direct bilirubin in predicting the diagnosis of se-nile diabetes mellitus type 2 complicated with coronary heart disease(T2DM-CHD).Methods A total of 412 senile patients undergoing coronary angiography in Department of Cardiovascular Medicine of Affiliated Hospital of Xuzhou Medical University from October 1,2022 to October 31,2023 were recruited and then divided into T2DM-CHD group(210 patients)and simple T2DM group(202 patients).Their general clinical information,glucose and lipid metabolism,liver and kidney functions and other indicators were collected simultaneously.Binary logistic regression analysis and Spearman non-parametric correlation analysis were used to determine the correlation between clinical indicators and diagnosis of T2DM-CHD,and ROC curve was plotted to analyze the AUC value of direct bilirubin in the diagnosis.Results The T2DM-CHD group exhibited sig-nificantly advanced age,larger male proportion,higher heart rate,elevated levels of HbA1c,fas-ting blood glucose,creatinine,direct bilirubin and apolipoprotein A-Ⅰ(ApoA-Ⅰ)and B(ApoB),but,decreased total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),albumin and indirect bilirubin when compared with the T2DM group(P＜0.05,P＜0.01).Binary logistic regression analysis indicated that creatinine,direct bilirubin,indirect bilirubin,and ApoB were associated with distinct diagnostic categories(P＜0.05,P＜0.01).Spearman non-parametric cor-relation analysis revealed that creatinine and direct bilirubin(r=0.198,P=0.000;r=0.697,P=0.000)were positively,while indirect bilirubin and ApoB(r=-0.141,P=0.003;r=-0.401,P=0.000)were negatively correlated with the incidence of T2DM-CHD.Direct bilirubin had an obvi-ously higher AUC value in the prediction of T2DM-CHD than creatinine,indirect bilirubin and ApoB(0.902 vs 0.641,0.419,0.268).Conclusion Direct bilirubin can be used as a key predictor for identifying senile patients of T2DM-CHD and simple T2DM.T2DM patients with direct biliru-bin＞3.89 μmol/L are susceptible to CHD.
Keywords：diabetes mellitustype 2coronary diseasebilirubindiagnosisforecasting
Publication Date：2024-08-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 882-885 )