Dynamic changes in infarction core volume and related factors in AIS-LVO patients

Yang Yang; Li Chunjiao

doi:10.3969/j.issn.1009-0126.2024.07.017

Abstract：Objective To investigate the dynamic changes in infarct core volume in patients with acute ischemic stroke due to large vascular occlusion(AIS-LVO)after treatment and analyze its related factors.Methods A total of 180 elderly AIS-LVO patients admitted to our department from January 2022 to December 2023 were recruited in this study.The age,past history,baseline National Institutes of Health Stroke Scale score,time from onset to admission,time from onset to CT perfusion imaging,and collateral circulation status of all patients were collected.After treat-ment,their final infarct core volume was 16.39±4.35 ml,and the growth rate of infarct core was 0.75±0.23 ml/h,and according to the growth rate,89 cases were assigned into group A(＞0.7 ml/h)and 91 cases into group B(≤0.7 ml/h).The dynamic changes in infarct core volume after treatment was evaluated with infarct core growth rate,and multivariate logistic regression was used to analyze the related factors affecting the dynamic changes.Results Group A had signifi-cantly higher baseline NIHSS score,longer time from onset to admission,longer time from onset to CT perfusion[14.52±2.40 vs 13.60±3.28,P=0.033;(3.16±0.44)h vs(3.01±0.39)h,P=0.017;(4.14±0.36)h vs(4.03±0.36)h,P=0.042],and lower collateral circulation score when compared with group B(2.11±0.35 vs 2.66±0.47,P=0.001).Multivariate logistic regression analysis showed that time from onset to admission(OR=0.311,95％CI:0.123-0.781,P=0.013)and collateral circulation score(OR=17.911,95％CI:7.717-41.943,P=0.001)were influencing factors for the change of infarct core volume in AIS-LVO patients after treatment.Conclusion The infarct core volume in patients with AIS-LVO presents dynamic changes after treatment,and it is related to the time from onset to admission and collateral circulation score.