Relationship of serum tau,MIP-1α and GFAP with BBB injury in patients after hypertensive cerebral hemorrhage
Li Yonghua
Li Ping
Zhang Honghong
Wang Zhisheng
Dong Yuan
Abstract：Objective To explore the relationship between serum levels of tau protein,macrophage inflammatory protein 1α(MIP-la)and glial fibrillary acidic protein(GFAP)with blood-brain bar-rier(BBB)injury after hypertensive cerebral hemorrhage.Methods A total of 180 patients with hypertensive cerebral hemorrhage and 180 healthy individuals taking physical examination in our hospital from August 2020 to December 2022 were recruited and assigned into study group and control group,respectively.Serum quotient of albumin(QAlb)was used to evaluate the severity of BBB injury,and the 180 patients in the study group were further divided into mild(QAlb:7.5-10,83 cases),moderate(10＜QAlb≤30,54 cases)and severe(QAlb＞30,43 cases)subgroups.All these patients were followed up for 6 months,and according to their modified Rankin Scale(mRS)score,they were assigned into good(mRS score:0-2,119 cases)and poor prognosis(3-6,61 cases)subgroups.The serum levels of tau protein,MIP-1α and GFAP were detected.The re-lationships of serum tau protein,MIP-1α and GFAP levels with BBB injury and prognosis were analyzed.Results The serum levels of tau protein,MIP-1α and GFAP were significantly higher in the study group than the control group(P＜0.01).The tau level in the moderate and severe sub-groups was obviously higher than that in the mild subgroup,and the MIP-1α and GFAP levels in the severe subgroup were notably higher than those in the mild subgroup(P＜0.05).The poor prognosis subgroup had remarkably higher serum tau,MIP-1α and GFAP levels than the good prognosis subgroup(P＜0.01).Serum tau protein(r=0.532,P=0.000),MIP-1α(r=0.487,P=0.001)and GFAP(r=0.571,P=0.000)were positively correlated with QAlb,respectively,and also with mRS score,separately(r=0.507,P=0.000;r=0.425,P=0.004;r=0.533,P=0.000).ROC curve analysis showed that the AUC value of the 3 proteins combined together in predicting prognosis was 0.848(95％CI:0.787-0.897,P=0.000),significantly greater than that of single indicator.Conclusion The levels of serum tau protein,MIP-1α and GFAP are significantly higher in patients with hypertensive cerebral hemorrhage than healthy people,and these indicators are closely associated with the severity of BBB injury and prognosis after cerebral hemorrhage.
Keywords：blood-brain barriertau proteinsmacrophage inflammatory proteinsglial fibrillary acidic protein
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 427-430 )