Efficacy of digoxin injection in treatment of acute heart failure combined with rapid atrial fibrillation
Zhang Yongwei
Li Yadi
Liang Haiqing
Zhang Yunqiang
Song Yu
Abstract：Objective To explore the efficacy of digoxin injection in the treatment of acute heart failure(HF)combined with rapid atrial fibrillation(AF).Methods A total of 956 acute HF pa-tients admitted in our CCU between January 2021 and December 2022 were selected,and 89 pa-tients complicated with rapid AF were screened from them according to the relevant diagnosis and medication regimen.Among them,47 cases were in the digoxin injection group and 42 cases were in the cedilanid group.Ventricular rate,left ventricular ejection fraction(LVEF),end-diastolic volume(LVEDV)and end-systolic volume(LVESV),serum creatinine,24-h urine volume(UV),and sST2,IL-6,and NT-proBNP levels were compared between the two groups.The incidence of MACE within 3 months after discharge was observed during the follow-up.Logistic regression analysis was used to analyze the influencing factors for MACE occurrence,and ROC curve analy-sis was employed to analyze the value of sST2,IL-6 and NT-proBNP alone and combined together in predicting MACE occurrence.Results The effective rate in 3 d after treatment was significant-ly higher in the digoxin injection group than the cedilanid group(P＜0.05).The heart rate was obviously lower in the former group than the latter group at 2 and 6 h after treatment(P＜0.05).The levels of sST2,IL-6 and NT-proBNP were decreased in both groups after treatment,with the levels in the digoxin injection group statistically lower than those in the cedilanid group(P＜0.05,P＜0.01).sST2,IL-6 and NT-proBNP were independent predictors for MACE occurrence in acute HF patients complicated with rapid AF(OR=1.031,95％CI:1.009-1.069;OR=1.045,95％CI:1.000-1.092;OR=1.000,95％CI:1.000-1.001).ROC curve analysis showed the AUC value of the combined 3 indicators in predicting MACE was 0.908(95％CI:0.828-0.959).Conclu-sion In the treatment of acute HF combined with rapid AF,digoxin injection can effectively im-prove the symptoms of chest tightness and palpitations,with advantages of rapid action and better control of heart rate when compared with cedilanid,and it will exert better therapeutic effects in consideration of the changes in sST2,IL-6,and NT-proBNP levels.The 3 indicators are independ-ent predictors of MACE in the patients,and their combination shows a greater predictive value in assessing the incidence of MACE for their prognosis.
Keywords：digoxindeslanosideheart failureatrial fibrillationmajor adverse cardiovascular events
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 372-376 )