Correlation between allele mutation of SR-B Ⅰ gene and high-density lipoprotein cholesterol in the elderly with coronary heart disease
Xia Wen
Wang Dong
Xiao Li
Abstract：Objective To explore the relationship between the mutation of exon 1 A allele of scav-enger receptor class B type Ⅰ(SR-BⅠ)and HDL-C.Methods A total of 280 patients with coro-nary heart disease(CHD)admitted in our department from January 2020 to December 2022 were recruited and served as observation group,and another 100 non-CHD individuals who taking phys-ical examination during the same period were enrolled as control group.The genotypes and alleles of SR-BⅠ exon 1 were detected,and the risk factors for CHD were analyzed.Results The per-centage of AA genotype and A allele was significantly higher in the observation group than the control group(P＜0.05).For all participants,higher proportions of hypertension and hyperlipi-demia,higher incidence of CHD onset and blood lipid level,while lower HDL-C level were ob-served in the GA+AA population than those without mutation(P＜0.05).Hypertension(OR=1.976,95％CI:1.093-3.571),hyperlipidemia(OR=2.179,95％CI:1.178-4.033),TC(OR=2.570,95％CI:1.060-6.233),HDL-C(OR=3.190,95％CI:1.403-7.252),and SR-BⅠ exon 1 A allele mutations(OR=2.300,95％CI:1.136-5.354)were independent risk factors for CHD(P＜0.05).SR-BⅠ exon 1 A allele mutation was positively correlated with hypertension,hyperlipi-demia,TC and LDL-C levels,and Gensini score(r=0.441,0.530,0.418,0.292,0.547,P＜0.05),and negatively with HDL-C(r=-0.536,P＜0.05).Conclusion The SR-BⅠ gene exon 1 A allele mu-tation is negatively correlated with HDL-C,and is an independent risk factor for CHD.
Keywords：coronary diseaseCD36 antigenscholesterolHDLallelesmutationrisk factors
Publication Date：2023-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1277-1280 )