Predictive value of combined three serum cytokine levels for delayed cerebral ischemia in patients after aSAH
Li Ke
Jin Xiao
Wang Yu
Abstract：Objective To investigate the predictive value of soluble tyrosine kinase-1(sFlt-1),chiti-nase protein 40(YKL-40)and lipoprotein phospholipase A2(Lp-PLA2)for delayed cerebral is-chemia(DCI)in patients after aneurysmal subarachnoid hemorrhage(aSAH).Methods A total of 100 aSAH patients treated in Department of Neurology of Nanyang First People's Hospital from January 2018 to December 2022 were enrolled,and then divided into DCI group(n=31)and non-DCI group(n=69).The levels of sFlt-1,YKL-40,and Lp-PLA2 in the serum were detected.ROC curve was plotted to evaluate the predictive value of serum sFlt-1,YKL-40 and Lp-PLA2 levels for DCI after aSAH.Results The serum levels of sFlt-1,YKL-40 and Lp-PLA2 were high-er in the DCI group than the non-DCI group(0.13±0.02 g/L vs 0.07±0.01 g/L,292.65±78.60μg/L vs 206.33±59.28 μg/L,396.59±41.12 μg/L vs 281.19±66.02 μg/L,P＜0.01).Logistic re-gression analysis revealed that elevated levels of sFlt-1,YKL-40 and Lp-PLA2,Hunt-Hess grade ≥3,modified Fisher grade ≥3,and WFNS grade ≥3 were risk factors for DCI after aSAH.ROC curve analysis showed that the AUC values of serum sFlt-1,YKL-40 and Lp-PLA2 levels in predicting DCI after aSAH was 0.806,0.789 and 0.893,respectively,and the value was 0.950 when the three indicators combined together.Conclusion Serum sFlt-1,Lp-PLA2 and YKL-40 levels are all elevated in the aSAH patients with DCI,and their combined detection is helpful for diagno-sing the occurrence of DCI after aSAH.
Keywords：subarachnoid hemorrhagebrain ischemiavascular endothelial growth factor receptor-1chitinases1-Alkyl-2-acetylglycerophosphocholine esteraseforecasting
Publication Date：2023-10-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1074-1077 )