Effect of rosuvastatin on expression of vascular endothelial growth factor in H type hypertension rats
Abstract：Objective To study the effect of rosuvastatin on expression of vascular endothelial growth factor (VEGF) in H type hypertension rats.Methods Twenty-four male SD rats were randomly divided into control group,H type hypertension group and H type hypertension+ rosuvastatin group (8 in each group).H type hypertension model was established by feeding rats with rat chow plus 2 ％ methionine.Serum VEGF level was measured by enzyme-link immunosorbent assay and expression of VEGF was detected with immunohistochemial staining.Results No significant difference was found in serum levels of TC,TG,HDL,LDL,Hcy between the control group,H type hypertension group and H type hypertension+rosuvastatin group (P＜0.05).The serum VEGF level was significantly higher in H type hypertension+ rosuvastatin group than in control group and H type hypertension group (217.50±30.40 ng/L vs 180.93± 15.75 ng/L,187.19± 10.93 ng/L,P＜0.05).The expression level of VEGF was significantly higher in H type hypertension+rosuvastatin group than in control group and H type hypertension group.Conclusion Rosuvastatin affects the vascular endothelial function in H type hypertension rats by regulating the expression of VEGF.
Keywords：hypertensionvascular endothelial growth factor Aenzyme-linked immunosorbent assayimmunohistochemistryhyperhomocysteinemiaantilipemic agents
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1313-1315 )