Association between post-stroke depression and cerebral small vessel disease in acute ischemic stroke patients
Abstract：Objective To study the association between PSD and CSVD in AIS patients.Methods Three hundred and one AIS patients were divided into PSD group (n =86) and non-PSD group (n=215).The patients underwent TOAST classification and were scored according to the NIHSS.The demographic data and risk factors for CSVD were recorded on admission.Results The age was older,the history of hypertension was longer,the NIHSS score,severe CSVD score and cerebral microbleeds (CMB) score were higher,the lacuna vasorum was larger in PSD group than in non-PSD group (P＜0.05).Logistic regression analysis showed that moderate CSVD score and severe CSVD score were the independent risk factors for PSD after adjustment of demographic data (age and gender) with mild CSVD as its reference (OR=1.32,95％CI:1.29-4.56,P=0.04;OR=3.02,95％CI:1.35-7.07,P=0.01).Moderate CSVD score could not predict PSD.However,severe CSVD score was associated with PSD after adjustment for P＜0.2 variables in univariate analysis and with age,gender,hypertension,DM,NIHSS score,and SBP with mild CSVD as its reference (OR=1.26,95％CI:0.96-4.16,P=0.65;OR=2.65,95％CI:1.11--6.92,P=0.04).Conclusion The severity of CSVD is closely associated with PSD in AIS patients.
Keywords：strokedepressionbrain infarctioncognition disordersbrain ischemiarisk factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1287-1290 )