Serum tenascin-C level and its clinical significance in ischemic stroke patients
Abstract：Objective To study the serum tenascin-C (TNC) level and its clinical significance in ischemic stroke patients.Methods Thirty-eight acute ischemic stroke (AIS) patients served as an experimental group and 28 age-and gender-matched subjects undergoing physical examination served as a control group in this study.Blood samples were taken to measure their serum TNC level by Luminex assay.The serum TNC level in 24 patients of experimental group was measured again on day 5 after onset of ischemic stroke.The etiology of TOAST was classified as large atherosclerotic ischemic stroke in 20 patients,unstable plaques in 8 patients and stable plaques in 12 patients of experimental group.Results The serum TNC level was significantly higher in experimental group than in control group (594.17±158.14 ng/L vs 504.98±110.80 ng/L,P＜0.05) and was significantly lower on day 5 than on day 1 after onset of ischemic stroke in 24 patients of experimental group (632.61±165.27 ng/L vs 657.90±133.02 ng/L,P＜0.05).The serum TNC level was significantly higher in atherosclerotic ischemic stroke patients with unstable plaques than in those with stable plaques (684.90±95.45 ng/L vs 519.21±149.69 ng/L,P＜0.05).Conclusion Elevated serum TNC level is possibly involved in cerebral ischemia,pathological injury and nerve repair in AIS patients.
Keywords：brain infarctiontenascinextracellular matrixmatrix metalloproteinase 9
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1283-1286 )