Association between CX3CR1 expression in monocytes and coronary artery stenosis

doi:10.3969/j.issn.1009-0126.2017.11.011

Abstract：Objective To study the association between CX3CR1 expression in monocytes and coronary artery stenosis (CAS).Methods Seventy patients with their CAS ≥50％ served as a stenosis group,23 patients with their CAS ＜50％ served as a non-significant lesion group and 24 volunteers with no CAS served as a control group.The CX3CR1 fluorescence intensity in monocytes was detected by flow cytometry.The CX3CR1 expression levels in 3 groups were compared.The related risk factors in CAS were analyzed by Spearman correlation analysis,multivariate logistic regression analysis and ROC curve analysis.Results The CX3CR1 fluorescence intensity was 4.94％ (2.41％,6.58％),2.02％ (1.25％,3.57％) and 1.68％ (1.09％,2.24％) respectively in stenosis group,non-significant lesion group and control group (P＜0.01).The CX3CR1 fluorescence intensity was singnificantly higher in stenosis group than in control group (P＜0.01).TG and CX3CR1 were the risk factors for CAS (P=0.048,P=0.026).The area under the ROC curve was 0.810 when the cut-off value was 2.91％,the sensitivity was 64.1％,and the specificity was 91.7％ for the CX3CR1 fluorescence intensity,indicating that CX3CR1 plays a certain role in diagnosis of CAS (P＜0.01).Conclusion The CX3CR1 expression level is significantly higher in CAS patients and is possibly involved in CAS.Elevated CX3CR1 expression level in monocytes is a risk factor for CAS and plays a certain role in diagnosis of CAS.