Relationship of cognitive function with serum Hcy level and Pon-1 activity in patients with non-dementia vascular cognitive impairment
Abstract：Objective To study the relationship of cognitive function and serum Hcy level and Pon-1 activity in patients with non-dementia vascular cognitive impairment (VCI).Methods Two hundred and one acute ischemic stroke (AIS) patients were divided into non-dementia VCI group (n=96) and control group (n=105) according to the MoCA Scale.Their serum Hcy level and Pon-1 activity were meausred.The relationship of cognitive impairment with serum Hcy level and Pon-1 activity was analyzed.Results The serum Hcy level was significantly higher while the Pon-1 activity was significantly lower in non-dementia VCI group than in control group (P＜0.05,P＜0.01).The total MoCA score,visual spatial/executive ability score,computational power score,language fluency score,abstraction ability score,delayed memory score and directional force score were significantly lower in non-dementia VCI group than in control group (P＜0.01).The serum Hcy level was negatively related with the total MoCA score,visual spatial/executive ability score,naming and attention ability score (r=-0.560,P＜0.01;r=-0.564,P＜0.01;r=-0.399,P＜0.01,r=-0.420,P＜0.05) while the PON-1 activity was positively related with the total MoCA score and visual spatial/executive ability score (r=0.432,r=0.463,P＜0.01).Conclusion Elevated serum Hcy level and decreased Pon-1 activity can show the different severities of connitive impairment and can thus be used as an objective indicator for the early diagnosis of non-dementia VCI.
Keywords：homocysteinedementiavascularcognition disordersrisk factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1133-1136 )