Characteristics of resting state functional connectivity strength in healthy elderly people based on apoEε4 allele gene typing
Abstract：Objective To study the mechaniams of apoEε4 allele gene underlying the topology structure of brain function network by analyzing the characteristics of resting state functional connectivity strength (FCS) in healthy elderly people based on apoEε4 allele gene typing.Methods The demographic data,MRI data and apoEε4 data of 44 healthy elderly people were collected from the Alzheimer's Disease Neuroimaging Initiative Database.The 44 healthy elderly people were divided into apoEε4 group (n=14) and non-apoEε4 group (n=30) according to whether they carried apoEe4 allele gene.They underwent resting state functional MRI (rs-fMRI) scanning and neuropsychological assessment.The whole brain long-range FCS and short-range FCS were calculated after the rs-fMRI data were preprocessed.The difference between the two groups was compared.Results The long-range FCS of the right insular lobe was significantly lower in apoEε4 group than in non-apoEε4 group in resting state (the cluster vlume was 183 voxels,14656.88±3762.93 vs 20905.82-±-10245.85,P＜0.05),the short-range FCS of the left and right insular lobes and the right hippocampus/fusiform ratio were also significantly lower in apoEε4 group than in nonapoEε4 group in resting state (the cluster volume was 91,232 and 75 voxels,P＜0.05).Conclusion Healthy elderly apoEε4 allele gene carriers do not show cognitive impairment,but their FCS is different from that of non-apoEε4 allele gene carriers,which may be due to the potential neurobiological effect of apoEε4 allele.
Keywords：apolipoproteins Eallelesmagnetic resonance imagingneuropsychologyAlzheimer disease
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1124-1128 )