Association of serum uric acid level with severity and outcome of acute ischemic stroke

doi:10.3969/j.issn.1009-0126.2017.10.018

Abstract：Objective To study the association of serum uric acid (UA) level with the severity and outcome of acute ischemic stroke (AIS).Methods Four hundred and ninety-six acute AIS patients were divided into high serum UA level group (n=119) and normal serum UA level group (n=377).Their demographic data,life style,history of disease,serum UA level were recorded on admission.Their neurological function was assessed at the time of admission and discharge.Their short-term outcomes were compared with the different serum UA levels (274 mmol/L,338 mmol/L and 411 mmol/L) as the interception points.Results The improved serum UA level and neurological function were significantly higher while the NIHSS score at discharge was significantly lower in high serum UA level group than in normal serum UA level group (438.30 ± 80.24 mmol/L vs 274.50±84.82 mmol/L,P=0.000;62.00％±22.00％ vs 57.00％ ±15.00％,P=0.005;4.80±2.21 vs 5.60±3.58,P=0.022).The poor outcome rate was significantly higher in patients with their serum UA level ≤274 μmol/L than in those with their serum UA level ≥412 μmol/L (45.2％ vs 29.6％,P＜0.05).Conclusion The serum UA level is not associated with the severity of AIS on admission.The elevated serum UA level contributes to the recovery of neurological function in early AIS patients,suggesting that high serum UA level plays a certain role in protecting against AIS.