Association of serum GGT level with intracranial and extracranial atherosclerotic stenosis in ischemic stroke patients
Abstract：Objective To study the association of serum GGT level with intracranial and extracranial atherosclerotic stenosis in ischemic stroke patients.Methods One hundred and forty-five ischemic stroke patients who underwent DSA in our hospital were divided into stenosis group (n=101) with their intracranial and extracranial atherosclerotic stenosis rate ≥50 ％ and control group (n=44) with their intracranial and extracranial atherosclerotic stenosis rate ＜50％.Their clinical data and laboratory testing data were recorded.The association of serum GGT level with intracranial and extracranial atherosclerotic stenosis was analyzed.Results The age was significantly older,the incidence of diabetes mellitus was significantly higher,the history of smoking was significantly longer,the serum levels of GGT,TG,LDL-C and hs-CRP were significantly higher in stenosis group than in control group (P＜0.05,P＜0.01).Logistic regression analysis showed that serum GGT level was one of the independent risk factors for intracranial and extracranial atherosclerotic stenosis in ischemic stroke patients (OR=1.048,95 ％CI:1.013-1.084,P=0.007).The incidence of intracranial and extracranial atherosclerotic stenosis increased with the elevating serum GGT level in ischemic stroke patients (x2 =13.170,P =0.004).Conclusion The serum GGT level is closely associated with intracranial and extracranial atherosclerotic stenosis and is thus an important risk factor for the development and progression of intracranial and extracranial atherosclerotic stenosis in ischemic stroke patients.
Keywords：gamma-glutamyltransferaseatherosclerosisalanine transaminaseC-reactive protein
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1058-1061 )