Effect of CPAP therapy on body fat and blood lipid in obstructive sleep apnea hypopnea syndrome patients
Abstract：Objective To study the effect of continuous positive airway pressure (CPAP) therapy on body fat and blood lipid in obstructive sleep apnea hypopnea syndrome (OSAHS) patients and its mechanism.Methods One hundred and twenty-six OSAHS patients admitted to the Chinese PLA General Hospital from January 2014 to January 2015 were included in this study.Their body mass index (BMI) and body fat rate were tested and their serum levels of TG,LDL-C,HDL-C and hs-CRP were measured on admission.Their AHI,BMI,minimum SaO2 and body fat rate were tested and their serum levels of TG,LDL-C,HDL-C and hs-CRP were measured after 6 months of CPAP therapy.Results The minimum SaO2 was significantly higher and the AHI,body fat rate,serum levels of LDL-C and hs-CRP were significantly lower in OSAHS patients after 6 months of CPAP therapy than before CPAP therapy (94.07％±2.15％ vs 74.54％±7.82％,P=0.001;5.88±2.36/h vs 27.61±7.38/h,P=0.001;26.51％± 1.77％ vs 31.62％±3.21％,P=0.008;2.04±0.55 mmol/L vs 3.75±0.81 mmol/L,P=0.005;4.48±1.03 mg/L vs 6.73±1.65 mg/L,P=0.009).Conclusion CPAP therapy can effectively improve OSAHS-induced intermittent hypoxia,and can thus alleviate inflammatory reaction and reduce body fat rate and serum LDL-C level in OSAHS patients.
Keywords：continuous positive airway pressuresleep apneaobstructiveadipositybody mass indexdyslipidemiasC-reactive protein
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1052-1054 )