Effect of depression on outcome in different ischemic heart failure patients

doi:10.3969/j.issn.1009-0126.2017.09.012

Abstract：Objective To analyze the effect of depression on the outcome in different ischemic heart failure (IHF) patients.Methods Five hundreds and thirty-five IHF patients (241 HFpEF patients,142 HFmrEF patients,122 HFrEF patients) were included in this study.Their depression was scored according to the PHQ-9.The patients were divided into depression group (n=218) and depression-free group (n=317).The severity of depression was divided into mild,moderate,moderate-severe and severe.The patients were followed up for 36 months and their accumulative survival rate was analyzed by Kaplan-Meier survival curve analysis.Results The total mortality was higher in depression group than in depression free group (39.00％ vs 30.16％,P=0.040).The accumulative survival rate decreased with the increasing PHQ-9 score (P=0.000).No significant difference was found in the total mortality of HFpEF and HFrEF patients (P=0.524,P=0.189).The mortality increased gradually with the severity of depression in HFrEF patients.However,the total mortality was significantly lower in HFrEF patients than in HFpEF and HFmrEF patients (38.89％ vs 52.94％,66.67％ vs 83.88％,P=0.014).The accumulative survival rate of HFpEF,HFmrEF and HFrEF patients decreased with the increasing severity of depression (P=0.000).Conclusion The effect of depression is diffrernt on the outcome in different IHF patients.Depresssion increases the mortality of HFrEF patients.